Education
Postdoctoral fellow, Pathobiology, University of Tennessee (2007)
Postdoctoral fellow, Nutritional Biochemistry, University of Wisconsin-Madison (2004)
Postdoctoral fellow, Growth physiology, Colorado State University (2002)
Ph. D. Animal Nutrition & Physiology, Korea University (1999)
M. S. Animal Nutrition, Korea University (1993)
B. S. Animal Science, Korea University (1991)
Professional Experience
Professor, Department of Nutrition and Food Science, University of Maryland (2024 Aug - )
Associate Professor, Department of Nutrition and Food Science, University of Maryland (2017 Aug - 2024 Aug)
Assistant Professor, Department of Nutrition and Food Science, University of Maryland (2011 Aug - 2017 Aug)
Research Assistant Professor, Department of Pathobiology, University of Tennessee (2007 Aug -2011 Aug)
Teaching
NFSC440/678R (Advanced Human Nutrition, 4 credits): 100% effort (2025 Fall - present)
NFSC620 (Diet and Cancer Prevention, 3 credits): 100% effort (2012 Fall - present)
NFSC436/636 (Diet and Optimal Human Health, 3 credits): 100% effort (2013 Spr - present)
NFSC100 Regular/Honor/FC (Elements of Nutrition, 3 credits): 25-33% involvement (2013 Fall - 2023 Fall) - Coordinated as a lead instructor (2013 Fall - 2017 Fall).
Research Expertise
Molecular Nutrition and Biochemistry
Molecular Carcinogenesis and Chemoprevention
Diet-related Chronic Disease Prevention
Nutritional and Environmental Toxicology
Publications * denotes corresponding author and # denotes authors Dr. Lee mentored
Peng J#, Amarakoon D#, Lee S-H* (2026) Knockdown of TRAPβ represses glucose uptake and energy production through multiple mechanisms in human colorectal cancer cells. Human Gene 48:201542. https://doi.org/10.1016/j.humgen.2026.201542
Fan R#, Joo YH#, Astawan M, Smolensky D, Lee S-H*, Wei C-I* (2026) Antiproliferative activity of soybean and tempeh extracts in human colorectal cancer cells. Food as Medicine 2(1):1-11. https://doi.org/10.53941/fm.2026.100001
Cho J, Cho C-H, Joo YH, Wei C-I, Lee S-H (2025) Tempeh, a fermented soybean, extends lifespan via MAPK pathway and improves healthy aging in Caenorhabditis elegans. Current Research in Food Science 10125. https://doi.org/10.1016/j.crfs.2025.101259
Amarakoon D#, Lee S-H* (2025) Role of the translocon-associated protein (TRAP)/signal sequence receptor (SSR) complex in the pathogenesis of human diseases. Human Gene 46:201510 (Review). https://doi.org/10.1016/j.humgen.2025.201510
Amarakoon D#, Peng J#, Wei C-I, Lee S-H* (2025) Knockdown of translocon-associated protein subunit beta (TRAPβ) stimulates cell cycle arrest and apoptosis in human colorectal cancer cells. BBA-Molecular Cell Research 1872:120057. PMID: 40925508
Peng J#, Wei C-I, Lee S-H* (2025) Eeyarestatin I (ESI)-induced ERAD inhibition exhibits anti-cancer activity through multiple mechanisms in human colorectal cancer cells. European Journal of Pharmacology 997:177623. PMID: 40222444
Santana Á, Peterson, J, Perumal R, Joo YH#, Lee, S-H, Siliveru K, Smolensky D (2025) High molecular weight polyphenols from sorghum bicolor retain higher glycation inhibition and cancer cell inhibition in vitro, compared to small molecular weight polyphenols after separation using Sephadex LH-20. ACS Food Science & Technology ACS Food Science & Technology 5:1010-1023. https://doi.org/10.1021/acsfoodscitech.4c00851
Amarakoon D#, Lee W-J#, Peng J#, Lee S-H* (2024) Identification of translocon-associated protein delta as an oncogene in human colorectal cancer cells. Journal of Cancer Prevention 29(4):175-184. PMID: 39790222
Ma P, Jia X, Zhang X, Li Y, He Y, Li T, Wu C, Joo YH, Lee S-H, Meng T, Brozena AH, Li S, Wang Q, Wei C-I, Briber RM, Mao Y, Hu L. (2024) Ion-chelated porous chitosan nanocrystal for highly efficient postharvest preservation. Matter 7:1-14. doi.org/10.1016/j.matt.2024.06.004
Tamia G#, Amarakoon D#, Wei C-I, Lee S-H* (2024) Evaluation of Humulus lupulus (hops) compound anti-proliferative properties with mechanisms in human colorectal cancer cells. Food Bioscience 57: 103493. doi.org/10.1016/j.fbio.2023.103493
Lee J#, Lee H-S#, Lee S-H* (2023) Preventive activity of patchouli alcohol against colorectal cancer and diabetes. Journal of Medicinal Food 26(4):255-261. PMID: 37071615
Amarakoon D#, Lee W-J#, Tamia G#, Lee S-H* (2023) Indole-3-carbinol: occurrence, health-beneficial properties, and cellular/molecular mechanisms. Annual Review of Food Science & Technology 14:347-366. (Review) PMID: 36972159
Li Y, Wu K, Liu Z, He X, Sun J, Zeng M, Lee, S-H, Wang T, Gao B, Xie Z, Wei C-I, Yu L (2022) Effect of thermal treatments on soluble free, soluble conjugated, and insoluble bound phenolic components and free radical scavenging properties of tomato seeds. ACS Food Science & Technology 2:1631-1638. DOI: https://doi.org/10.1021/acsfoodscitech.2c00228
Lee H-S#, Amarakoon D#, Tamia G#, Park Y, Smolensky D, Lee S-H* (2022) Pendimethalin induces apoptotic cell death through activating ER stress-mediated mitochondrial dysfunction in human umbilical vein endothelial cells. Food and Chemical Toxicology 168:113370. PMID: 35985363
Lee H-S#, Song H-J, Park Y, Smolensky D, Lee S-H* (2022) Permethrin inhibits tube formation and viability of endothelial cells. Journal of the Science of Food and Agriculture 102:4079-4085. PMID: 34997580
Li Y, Liu Z, Tamia GM#, He X, Sun J, Chen P, Lee, S-H, Wang T, Gao B, Xie Z, Yu L (2022) Soluble free, soluble conjugated and insoluble bound phenolics in tomato seeds and their radical scavenging and antiproliferative activities. Journal of Agricultural and Food Chemistry 70(29):9039-9047. PMID:35820155
Lee H-S#, Tamia G#, Song H-J, Amarakoon D#, Wei C-I, Lee S-H* (2022) Cannabidiol exerts anti-proliferative activity via a cannabinoid receptor 2-dependent mechanism in human colorectal cancer cells. International Immunopharmacology 108:108865. PMID:35598400
Lee H-S#, Santana ÁL, Peterson J, Yucel U, Perumal R, De Leon J, Lee S-H*, Smolensky D* (2022) Anti-adipogenic activity of high phenolic sorghum brans in pre-adipocytes. Nutrients 14:1493. PMID: 35406112
Lee W-J#, Lee S-H* (2022) Protocatechuic acid protects hepatocytes against hydrogen peroxide-induced oxidative stress. Current Research in Food Science 5:222-227. PMID: 35106486
Lee K, Yu H, Shouse S, Kong B, Lee J#, Lee S-H, Ko KS (2021) RNA-Seq reveals different gene expression in liver-specific prohibitin 1 knock-out mice. Frontiers in Physiology 12:717911 PMID: 34539442.
Lee S-H*, Lee H-S#, Lee J#, Amarakoon D#, Lou Z#, Noronha LE, Herald TJ, Perumal R, Smolensky D (2021) Polyphenol containing sorghum brans exhibit an anti-cancer effect in Apc Min/+ mice treated with dextran sodium sulfate. International Journal of Molecular Sciences 22(15):8286 PMID:34361052
Lee H-S#, Amarakoon D#, Wei C-I, Choi KY, Smolensky D, Lee S-H* (2021) Adverse effect of polystyrene microplastics (PS-MPs) on tube formation and viability of human umbilical vein endothelial cells. Food and Chemical Toxicology 154:112356 PMID:34157338
Kang SU, Kim DH, Lee YS, Huang M, Byeon HK, Lee S-H, Baek SJ, Kim C-H (2021) DIM-C-pPhtBu induces lysosomal dysfunction and unfolded protein response-mediated cell death via excessive mitophagy. Cancer Letters 504:23–36 PMID: 33556544
Amarakoon D#, Lou Z#, Lee W-J#, Smolensky D, Lee S-H* (2021) A mechanistic review: potential chronic disease-preventive properties of sorghum. Journal of the Science of Food and Agriculture 101: 2641–2649. (Review) PMID: 33179254
Peng M, Lee S-H, Rahaman SO, Biswas D (2020) Dietary probiotic and metabolites improve intestinal homeostasis and prevent colorectal cancer. Food & Function 11(12):10724-10735. PMID: 33231228
Lee H-S#, Lee J#, Smolensky D, Lee S-H* (2020) Potential benefits of patchouli alcohol in prevention of human diseases: a mechanistic review. International Immunopharmacology 89(Pt A):107056 (Review). PMID:33039955.
Lee S-H, Lee J#, Herald T, Cox S, Noronha L, Perumal R, Lee H-S#, Smolensky D (2020) Anti-cancer activity of a novel high phenolic sorghum bran in human colon cancer cells. Oxidative Medicine and Cellular Longevity, 2020:2890536. PMID:33082907.
Lee J#, Kong B, Lee S-H* (2020) Patchouli alcohol, a compound from Pogostemon cablin, inhibits obesity. Journal of Medicinal Food 23(3):326-334. PMID:31750759
Song Z, Li Y, Gao B, Lee J#, Wu Y, Sun J, Whent M, Chen P, Lee S-H, Yu L (2020) The chemical composition, antioxidant activity, and antiproliferative activity of selected seed flours. Journal of Food Bioactives 10:77-85.
Farias-Pereira R, Savarese J, Yue Y, Lee S-H, Park Y (2020) Fat-lowering effects of isorhamnetin are via NHR-49-dependent pathway in Caenorhabditis elegan. Current Research in Food Science, 2:70-76. PMID:32914113.
Cox S, Noronha L, Herald T, Bean S, Lee S-H, Perumal R, Wang W, Smolensky D (2019) Evaluation of ethanol-based extraction conditions of sorghum bran bioactive compounds with downstream anti-proliferative properties in human cancer cells. Heliyon, 5(5):e01589. PMID:31111105
Ha T#, Lee J#, Lou Z#, Lee B-S, Kim C-H, Lee S-H* (2019) Identification of epithelial-specific ETS-1 (ESE-1) as a tumor suppressor and molecular target of green tea compound, EGCG. Molecular Carcinogenesis 58(6):922-932. PMID:30676667
Lou Z#, Lee B-S, Ha T#, Xu Y#, Kim H-J, Kim C-H*, Lee S-H* (2018) ESE-1 suppresses the growth, invasion and migration of human NSCLC cells and tumor formation in vivo. Oncology Reports 40(3):1734-1742. PMID:30015943
Zhang J, Teng Z, Yuan Y, Zeng QZ, Lou Z#, Lee S-H, Wang Q (2018) Development, physicochemical charaterization and cytotoxicity of selenium nanoparticles stabilized by beta-lactoglobulin. International Journal of Biological Macromolecules 107(PtB):1406-1413. PMID:29017880
Feldman D#, Leahy E#, Lee S-H* (2018) Chemopreventive properties of tolfenamic acid: a mechanistic review. Current Medicinal Chemistry 25(14):1598-1608 (Review). PMID:28413959
Xu Y#, Lou Z#, Lee S-H* (2017) Arctigenin represses TGF-β-induced epithelial mesenchymal transition in human lung cancer cell. Biochem. Biophys. Res. Commun. 493(2):934-939. PMID:28951214
Lee J#, Yue Y, Park Y, Lee S-H* (2017) 3,3'-diindolylmethane suppresses adipogenesis using AMPKα-dependent mechanism in 3T3-L1 adipocytes and Caenorhabditis elegans. Journal of Medicinal Food 20(7):646-652. PMID:28459610
Lee J#, Imm J-Y, Lee S-H* (2017) β-catenin mediates anti-adipogenic and anti-cancer effects of arctigenin in preadipocytes and breast cancer cells. Journal of Agricultural and Food Chemistry 65(12):2513-2520. PMID:28279068
Lee S-H*, Clark R# (2016) Anti-tumorigenic effects of capsaicin in colon cancer. Journal of Food Chemistry and Nanotechnology 2(4):162-167. DOI:10.17756/jfcn.2016-025
Shin YS, Kang SU, Park JK, Kim YE, Kim YS, Baek SJ, Lee S-H, Kim C-H (2016) Anti-cancer effect of epigallocatechin-3-gallate (EGCG) in head and neck cancer through repression of transactivation and enhanced degradation of β-catenin. Phytomedicine 23:1344-1355. PMID:27765354
Silva G, Marins M, Fachin AL, Lee S-H, Baek SJ (2016) Anti-cancer activity of trans-chalcone in osteosarcoma: Involvement of Sp1 and p53. Molecular Carcinogenesis 55(10):1438-1448. PMID:26294168
Yang X#, Lee S-H* (2016) Identification of ESE1 as a β-catenin binding protein. Anticancer Research 36(6):2697-2704. PMID:27272778
Ha T#, Lou Z#, Baek SJ, Lee S-H* (2016) Tolfenamic acid downregulates β-catenin in colon cancer. International Immunopharmacology 35:287–293. PMID:27089389
Min K-W, Lee S-H, Baek SJ (2016) Moonlighting proteins in cancer. Cancer Letters 370:108-116. (Review). PMID:26499805
Clark R#, Lee S-H* (2016) Anticancer properties of capsaicin against human cancer. Anticancer Research 36(3):837-844. (Review) PMID:26976969
Jiang X#, Kim K-J#, Ha T#, Lee S-H* (2016) Potential dual role of activating transcription factor 3 in colorectal cancer. Anticancer Research 36(2):509-516. PMID:26851004
Wong J, Kim Y, Park Y, Lee S-H, Baek SJ, Park Y (2015) Isomer specificity of conjugated linoleic acid on suppression of osteosarcomas. J. Nature Sci. 1: e67.
Liu J, Yang P, Shi H, Sun X, Lee S-H, Yu L (2015) A novel Gynostemma pentaphyllum saponin and its adipogenesis inhibitory effect through modulating Wnt/β-catenin pathway and cell cycle in mitotic clonal expansion. Journal of Functional Foods 17: 552-562. DOI:10.1016/j.jff.2015.06.014
Jeong JB#, Lee J#, Lee S-H* (2015) TCF4 is a molecular target of resveratrol in the prevention of colorectal cancer. International Journal of Molecular Sciences 16:10411-10425. PMID:25961950
Clark R#, Lee J#, Lee S-H* (2015) Synergistic anti-cancer activity of capsaicin and 3,3’-diindolylmethane in human colorectal cancer. Journal of Agricultural and Food Chemistry 63(17):4297-4304. PMID:25876645
Shao HJ#, Jeong JB#, Kim K-J#, Lee S-H* (2015) Anti-inflammatory activity of mushroom-derived hispidin through blocking of NF-kB activation. Journal of the Science of Food and Agriculture 95(12):2482-2486. PMID:25355452
Kim K-J#, Lee J#, Park Y, Lee S-H* (2015) ATF3 mediates anti-cancer activity of trans-10, cis-12-conjugated linoleic acid in human colon cancer cells. Biomolecules&Therapeutics 23(2):134-140. PMID: 25767681
Shao HJ#, Lou Z#, Jeong JB, Kim K-J#, Lee J#, Lee S-H* (2015) Tolfenamic acid suppresses inflammatory stimuli-mediated activation of NF-ĸB signaling. Biomolecules&Therapeutics 23(1):39-44. PMID:25593642
Choi J#, Jiang X#, Jeong JB#, Lee S-H* (2014) Anti-cancer activity of protocatechualdehyde in human breast cancer cells. Journal of Medicinal Food 17(8):842-848 PMID:24712725
Chang JW, Kang SU, Choi JW, Shin YS, Baek SJ, Lee S-H, Kim C-H (2014) Tolfenamic acid induces apoptosis and growth inhibition in anaplastic thyroid cancer: Involvement of nonsteroidal anti-inflammatory drug-activated gene-1 expression and intracellular reactive oxygen species generation. Free Radical Biology and Medicine 67:115-130. PMID:24216474
Chrysovergis K, Wang X, Kosak J, Lee S-H, Kim JS, Foley JF, Travlos G, Singh S, Baek SJ, Eling TE (2014) NAG-1/GDF15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism. International Journal of Obesity 38(12):1555-1564. PMID:24531647
Zhang X, Lee S-H, Min K-W, McEntee MF, Jeong JB#, Li Q, Baek SJ (2013) The involvement of endoplasmic reticulum stress in the suppression of colorectal tumorigenesis by tolfenamic acid. Cancer Prevention Research 6(12):1337-1347. PMID:24104354
Jeong JB#, Yang X#, Clark R#, Choi J#, Baek SJ, Lee S-H* (2013) A mechanistic study of the proapoptotic effect of tolfenamic acid; involvement of NF-κB activation. Carcinogenesis 34:2350-2360. PMID:23784084
Jeong JB#, Choi J#, Baek SJ, Lee S-H* (2013) Reactive oxygen species mediate tolfenamic acid-induced apoptosis in human colorectal cancer cells. Archives of Biochemistry and Biophysics 537:168-175. PMID:23896514
Jeong JB#, Choi J#, Lou Z#, Jiang X#, Lee S-H* (2013) Patchouli alcohol, essential oil of Pogostemon cablin, exhibits anti-tumorigenic activity in human colorectal cancer cells. International Immunopharmacology 16:184-190 PMID:23602914
Jeong JB#, Shin YK#, Lee S-H* (2013) Anti-inflammatory activity of patchouli alcohol in RAW264.7 and HT-29 cells. Food and Chemical Toxicology 55:229-233 PMID:23348408
Jeong JB#, Lee S-H* (2013) Protocatechualdehyde possesses anti-cancer activity through downregulating cyclin D1 and HDAC2 in human colorectal cancer cells. Biochem. Biophys. Res. Commun 430:381-386. PMID:23159608
Kang SU, Lee B-S, Lee S-H, Baek SJ, Shin YS, Kim C-H (2013) Expression of NSAID activated gene-1 by EGCG in head and neck cancer: Involvement of ATM-dependent p53 expression. Journal of Nutritional Biochemistry 24:986-999 PMID:23017582
Kim J, Park Y, Lee S-H, Park Y (2013) trans-10,cis-12 conjugated linoleic acid promotes bone formation by inhibiting adipogenesis by peroxisome proliferator activated receptor-γ dependent mechanisms and by directly enhancing osteoblastogenesis from bone marrow mesenchymal stem cells. Journal of Nutritional Biochemistry 24:672–679. PMID:22832076
Kang SU, Shin YS, Hwang HS, Baek SJ, Lee S-H, Kim C-H (2012) Tolfenamic acid induces apoptosis and growth inhibition in head and neck cancer: Involvement of NAG-1 expression. PLoS ONE 2012;7(4):e34988. PMID:22536345
Lee S-H, Min KW, Zhang X, Baek SJ (2013) 3,3'-diindolylmethane induces activating transcription factor 3 (ATF3) via ATF4 in human colorectal cancer cells. Journal of Nutritional Biochemistry 24:664-671 PMID:22819556
Nualsanit T, Rojanapanthu P, Gritsanapan W, Lee S-H, Lawson D and Baek SJ (2012) Damnacanthal, a Noni component, exhibits anti-tumorigenic activity in human colorectal cancer cells. Journal of Nutritional Biochemistry 23:915-923 PMID:21852088
Lee S-H*, Richardson RL, Dashwood RH, Baek SJ (2012) Capsaicin represses transcriptional activity of β-catenin in human colorectal cancer cells. Journal of Nutritional Biochemistry 23:646-655. PMID:21764279
Margraves C, Kihm K, Yoon SY, Choi CK, Lee S-H, Liggett J, Baek SJ (2011) Simultaneous measurements of cytoplasmic viscosity and intracellular vesicle sizes for live human brain cancer cells. Biotechnology & bioengineering 108: 2504–2508. PDIM:21520025
Krisanapun C, Lee S-H, Peungvicha P, Temsiririrkkul R, Baek SJ (2011) Antidiabetic activities of abutilon indicum (L.) sweet are mediated by enhancement of adipocyte differentiation and activation of the GLUT1 promoter. Evidence-based Complementary and Alternative Medicine. 2011:167684. PMID:21603234
Whitlock NC, Bahn JH, Lee S-H, Eling TE, Baek SJ (2011) Resveratrol-induced apoptosis is mediated by early growth response-1, krüppel-like factor 4, and activating transcription factor 3. Cancer Prevention Research 4:116–127. PMID:21205742
Kim C-H, Bahn JH, Lee S-H, Kim G-Y, Jun S, Lee K, Baek SJ (2010) Induction of cell growth arrest by atmospheric non-thermal plasma in colorectal cancer cells. Journal of Biotechnology 150:530–538. PMID: 20959125
Zhong Y, Krisanapun C, Lee S-H, Nualsanit T, Sams C, Peungvicha P, Baek SJ (2010) Molecular targets of apigenin in colorectal cancer cells: Involvement of p21, NAG-1 and p53. Eur J Cancer. 46:3365-3374. PMID: 20709524
Lee S-H, Bahn JH, Whitlock NC, Baek SJ (2010) Activating transcription factor 2 (ATF2) controls tolfenamic acid-induced ATF3 expression via MAP kinase pathways. Oncogene 29: 5182–5192. PMID: 20581861
Cekanova M, Lee S-H, McEntee MF, Baek SJ (2010) MCC-555-induced NAG-1 expression is mediated in part by KLF4. Eur. J. Pharmacol. 637: 30–37. PMID: 20385121
Lee S-H, Krisanapun C, Baek SJ. (2010) NSAID-activated gene-1 as a molecular target for capsaicin-induced apoptosis through a novel molecular mechanism involving GSK3β, C/EBPβ, and ATF3. Carcinogenesis 31(4):719-728. PMID: 20110283
Choi CK, Sukhthankar M, Kim C-H, Lee S-H, English A, Kihm KD, Baek SJ (2010) Cell adhesion property affected by cyclooxygenase and lipoxygenase: Opto-electric approach. Biochem. Biophys. Res. Commun. 391:1385-1389. PMID: 20026301
Cekanova M, Lee S-H, Donnell RL, Sukhthankar M, Eling TE, Fischer SM, Baek SJ (2009) Nonsteroidal Anti-inflammatory Drug-Activated Gene-1 Expression Inhibits Urethane-Induced Pulmonary Tumorigenesis in Transgenic Mice. Cancer Prevention Research 2(5):450-458. PMID: 19401523
Iguchi G, Chrysovergis K, Lee S-H, Baek SJ, Langenbach R, Eling TE (2009) A reciprocal relationship exists between non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) and cyclooxygenase-2. Cancer Letter 282(2):152-158. PMID: 19375854
Lee S-H, Bahn JH, Choi CK, Whitlock NC, English AE, Safe S, Baek SJ (2008) ESE-1/EGR-1 pathway plays a role in tolfenamic acid-induced apoptosis in colorectal cancer cells. Molecular Cancer Therapeutics 7(12):3739-3750. PMID: 19074849
Sukhthankar M, Yamaguchi K, Lee S-H, McEntee MF, Eling TE, Hara Y, Baek SJ (2008) A green tea component suppresses post-translational expression of basic fibroblast growth factor in colorectal cancer. Gastroenterology 134:1972-1980. PMID: 18549879
Lee S-H, Cekanova M, Baek SJ (2008) Multiple mechanisms are involved in 6-gingerol-induced cell cycle arrest and apoptosis in human colorectal cancer cells. Molecular Carcinogenesis 47:197-208. PMID: 18058799
Cho K-N, Sukhthankar M, Lee S-H, Yoon J-H, Baek SJ (2007) Green tea catechin epicatechin gallate induces tumor suppressor protein ATF3 via EGR-1 activation. Eur J Cancer 43:2404-2412. PMID: 17764926
Lim YC$, Lee S-H$, Song MH, Yamaguchi K, Yoon J-H, Choi EC, Baek SJ (2006) Growth inhibition and apoptosis by (-)-epicatechin gallate are mediated by cyclin D1 suppression in head and neck squamous carcinoma cells. Eur J Cancer 42:3260-3266. PMID: 17045795 $equally contributed
Baek SJ, Okazaki R, Lee S-H, Martinez J, Kim J-S, Yamaguchi K, Mishina Y, Martin DW, Shoieb A, McEntee MF, Eling TE (2006) Nonsteroidal anti-inflammatory drug activated gene-1 over-expression in transgenic mice suppresses intestinal neoplasia. Gastroenterology 131(5):1553-1560. PMID: 17101328
Yamaguchi K, Lee S-H, Eling TE, Baek SJ (2006) A novel peroxisome proliferator-activated receptor γ ligand, MCC-555, induces apoptosis via posttranscriptional regulation of NAG-1 in colorectal cancer cells. Molecular Cancer Therapeutics 5(5):1352-1361. PMID: 16731769
Lee S-H, Yamaguchi K, Kim J-S, Eling TE, Safe S, Park Y, Baek SJ (2006) Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner. Carcinogenesis 27(5):972-981. PMID: 16286461
Yamaguchi K, Lee S-H, Kim J-S, Wimalasena J, Kitajima S, Baek SJ (2006) Activating transcription factor 3 and early growth response-1 are the novel targets of LY294002 in a PI3K independent pathway. Cancer Research. 66:2376-2384. PMID: 16489044
Kim J-H, Yamaguchi K, Lee S-H, Tithof, PK, Sayler GS, Yoon J-H, Baek SJ (2005) Evaluation of polycyclic aromatic hydrocarbons in the activation of early growth response-1 and peroxisome proliferator activated receptors. Toxicol. Sci. 85:585-593. PMID: 15716483
Lee S-H, Kim J-S, Yamaguchi K, Eling TE, Baek SJ (2005) Indole-3-carbinol and 3,3'-diindolylmethane induce expression of NAG-1 in a p53 independent manner. Biochem. Biophys. Res. Commun. 328:63-69. PMID: 15670751
Baek SJ, Kim J-S, Moore SM, Lee S-H, Martinez J, Eling TE (2005) Cyclooxygenase inhibitors induce the expression of the tumor suppressor gene EGR1, which results in the up-regulation of NAG-1, an anti-tumorigenic protein. Mol. Pharmacol. 67(2):356-364. PMID: 15509713
Baek SJ, Kim J-S, Jackson FR, Eling TE, McEntee MF, Lee S-H (2004) Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells. Carcinogenesis 25(12):2425-2432. PMID: 15308587
Yamaguchi K, Lee S-H, Eling TE, Baek SJ (2004) Identification of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) as a novel downstream target of phosphatidylinositol 3-kinase/AKT/GSK-3β pathway. J. Biol. Chem. 279(48): 49617-49623. PMID: 15377673
Dobrzyn A, Dobrzyn P, Lee S-H, Miyazaki M, Cohen P, Asilmaz E, Hardie DH, Friedman JM, Ntambi JM (2005) Stearoyl-CoA desaturase 1 deficiency reduces ceramide synthesis by down-regulating serine palmitoyltransferase and increasing b-oxidation in skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 288:E599-607. PMID: 15562249
Rahman SM, Dobrzyn A, Lee S-H, Dobrzyn P, Miyazaki M, Ntambi JM (2005) Stearoyl-CoA desaturase 1 deficiency increases insulin signaling and glycogen accumulation in brown adipose tissue. Am. J. Physiol. Endocrinol. Metab. 288:E381-387. PMID: 15494611
Lee S-H, Dobrzyn A, Dobrzyn P, Rahman SM, Miyazaki M, Ntambi JM (2004) Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis, but causes hypothermia in cold environment. J. Lipid Res. 45(9):1674-1682. PMID: 15210843
Miyazaki M, Dobrzyn A, Sampath H, Lee S-H, Man WC, Chu K, Peters JM, Gonzalez FJ, Ntambi JM (2004) Reduced adiposity and liver steatosis by stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated receptor-α. J. Biol. Chem. 279(33):35017-35024. PMID: 15180999
Rahman SM, Dobrzyn A, Dobrzyn P, Lee S-H, Miyazaki M, Ntambi JM (2003) Stearoyl-CoA desaturase 1 deficiency elevates insulin signaling components and downregulates protein-tyrosine phosphatase 1B in muscle. Proc. Natl. Acad. Sci. USA. 100(19):11110-11115. PMID: 12960377
Lee S-H, Hossner KL (2002) Effects of bovine colostral ultrafiltrates on growth and differentiation of 3T3-L1 preadipocytes. Biotechnol Appl Biochem. 36:205-212. PMID: 12452804
Lee S-H, Hossner KL (2002) Coordinate regulation of ovine adipose tissue gene expression by propionate. J. Anim. Sci. 80(11):2840-2849. PMID: 12462251
Lee S-H, Engle TE, Hossner KL (2002) Effects of dietary copper on the expression of lipogenic genes and metabolic hormones in steers. J. Anim. Sci. 80(7):1999-2005. PMID: 12162670
Lee S-H, Kim KD, Ko KS, Son YS (2000) Retinoic acid level and function of porcine thyroid cells in vitro. Korean J. Anim. Sci. Technol. 42(2):165-172.
Lee S-H, Hong SH, Son YS (1999) Studies on the substances modulating nitrate and nitrite reduction by rumen microbes. Korean J. Anim. Nutr. Feed. 23(5):411-418.
Son Y-S, Kim S-H, Hong S-H, Lee S-H (1998) Effect of feeding bentonite and granite porphyry on ruminal buffering activity and fermentation pattern. Korean J. Dairy Sci. 20(1):21-32.
Han H-C, Lee S-H, Son Y-S (1994) In situ and in vitro evaluations of some feed proteins heat-treated by different processing methods. Korean J. Anim. Nutr. Feed 18(6):491-498.
Son Y-S, Yu B-W, Han H-C, Lee S-H, Lee C-J, Kim K-S (1994) A field study on the ruminal pH of lactating cows according to feeding system in Korea. Korean J. Dairy Sci. 16(4):326-334.
Lee S-H, Son Y-S (1993) Characteristics of nitrate reduction by rumen microorganism and responses of host animal to prolonged nitrate intake. Korean J. Dairy Sci. 15(4):261-270.
