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Professor

Plant Science & Landscape Architecture 5140 Plant Sciences Building 4291 Fieldhouse Drive College Park, Maryland 20742

RESEARCH FOCUS

  • Processes that control the movement of the phytohormone auxin to regulate programmed and plastic plant development
  • Integration of light and gravity responses and modification of auxin fluxes by salt stress.
  • Transport of other aromatic acids that function in plant / fungal growth processes.
  • Reduction of mycotoxins in plant foods

Biography

Biography: 

Research in the lab is focused on the processes that control the movement of the phytohormone auxin to regulate programmed and plastic plant development.  Much of the work focuses on how those processes respond to environmental inputs and stress. Current efforts involve integration of light and gravity responses and modification of auxin fluxes by salt stress. The lab also studies the transport of other aromatic acids that function in plant / fungal growth processes. We use the tools of structural biology, modeling, biochemistry, cell biology, comparative systems biology, and molecular genetics in our work.

Education: 

B.A. (Honors), University of California, Santa Cruz, Biology
Ph. D, University of California, Santa Cruz

Awards and Honors: 

2007-2012 Purdue University Faculty Scholar. Purdue University
2006 BBSRC Underwood Fellow. Dept Plant Sciences, University of Oxford

Professional Work

Professional Positions Held: 

2012- Present Professor and Chair, Plant Science & Landscape Architecture, University of Maryland, College Park
2008-2012 Professor, Dept. Horticulture Landscape Architecture, Purdue University
2005-2008 Assoc. Professor, Dept. Horticulture Landscape Architecture, Purdue University
2003-2012 Adjunct Professor of Biology, University of Texas Pan American
2001-2005 Asst. Professor, Dept. Horticulture Landscape Architecture, Purdue University
1999-2000 Assistant Research Biologist, University of California, Santa Cruz (UCSC)
1996-1999 Post-doctoral Fellow, UCSC

Professional Service: 

Member: AAAS, ASPB, ASHS, ASBMB, SEB, MNLGA

Editorial Board: Journal Experimental Botany, Plant and Cell Physiology, Frontiers in Plant Science

Research

Areas of Interest: 

  • Auxin Transport

  • ABC Transporter

  • Phototropism

  • Membrane nano domains

  • Hormone/Herbicide Crosstalk

Current Research: 

 

 

Plant hormone transport and growth

 

Plant hormone transport and growth

One of the longest standing projects in the lab investigates the cellular mechanisms that regulate auxin transport in dicots (Arabidopsis, tomato, cucurbits) and monocots (rice, maize, sorghum). This work has included mechanistic studies of auxin transporters and their regulation, differentiation of long distance and localized vectorial auxin transport streams, and the contributions of these streams to plant architecture and plastic responses to light and nutrients. Over the past two decades, the lab has played a major role in identifying and characterizing the auxin transport proteins from the ATP-Binding Cassette class B (ABCB) family, characterizing the subcellular mechanisms that regulate their activity, and clarifying their interactions with the PIN family of auxin transporters. More recent work has focused on light / gravity regulation of auxin transport and the impacts of salt stress on these processes. Funding for this project has come from the National Science Foundation, the Department of Energy, the US Department of Agriculture, and the Biotechnology and Biological Sciences Research Council (UK).

 

Structure-function analyses of ABCB transporters

 

Structure-function analyses of ABCB transporters

b focuses on elucidation of the structural features of plant ABCB transporters that confer the relative substrate specificity as well as some conditional uptake.  A major focus of this work is the generation of new ABC transporters to enhance production of engineered biofuel precursors. This work is funded by the Basic Energy Sciences Division of the  U.S Department of Energy.

 

 

herbicide uptake in plants and mammals

 

 

Herbicide uptake in plants and mammals

Movement of environmentally-applied herbicides into non target sites is a major public concern. This project in the lab was originally directed to understanding of the extent to which herbicides “drift” onto non-target crops and ornamentals, but, more recently, has also examined movement of herbicides into pets and households.

Teaching

Courses Taught: 

PLSC399: SPECIAL PROBLEMS IN PLSC Spring 2014, Spring 2015, Spring 2016, Summer 2016
PLSC400: ENVIRON PLANT PHYSIOLOGY Spring 2013
PLSC489T:  SEMINAR  IN PLANT SCIENCE AND LARC Spring 2014
PLSC608: RESEARCH METHODS Fall 2013, Fall 2014, Fall 2015, Fall 2016
PLSC608T: SUPERVISED TEACHING Fall 2013, Fall 2014, Fall 2015, Fall 2016
PLSC798: GRADUATE SEMINAR Fall 2013
PLSC789F: CRTQ PRMRY PLNT SCI LIT Spring, 2014, Spring 2015
PLSC789M: PLANT MEMBRANE BIOLOGY

Spring 2013, Summer 2013, Fall 2013, Spring 2014,

Summer 2014, Fall 2014, Sprign 2015, Summer 2015, Spring 2016

 

Publications

Selected Publications: 

1.    Jinsong Dong, Miguel Pineros, Xiaoxuan Li, Haibing Yang, Yu Liu, Angus Murphy, Leon Kochian, and Dong Liu (2016) An Arabidopsis ABC transporter mediates phosphate deficiency-induced remodeling of root architecture by modulating iron homeostasis in roots.  Mol. Plant MPLANT/2016/045864

2.  Wei H, Lin C-Y, Jakes JE, Donohoe BS, Ciesielski PN, Yang H, Gleber S-C, Vogt S, Ding S-Y, Peer WA, Murphy AS, McCann MC, Himmel ME, Tucker MP. (2016) Directed plant cell wall accumulation of iron: Embedding co-catalyst for efficient biomass conversion. Biotechnology for Biofuels, in press.

3.    Yang, H., Wei, H., Ma, G., Antunes, M.S., Vogt, S., Cox, J., Zhang, X., Liu, X., Bu, L., Gleber, S.C., Carpita, N.C., Makowski, L., Himmel, M.E., Tucker M.P., McCann M.C., Murphy, A.S., Peer, W.A. (2016) Cell wall targeted in planta iron accumulation enhances biomass conversion and seed iron concentration in Arabidopsis and rice. Plant Biotechnol. J., doi: 10.1111/pbi.12557

4.     Ling, Guan, A. S. Murphy, W. A. Peer, L. J. Gan, Y. Li, and Z. Cheng.  2015.  Physiological and molecular regulation of adventitious root formation.  Critical Reviews in Plant Sciences, Vol 34 pages 506-521.

5.    Blakeslee J and Murphy AS (2015) Microscopic and Biochemical Visualization of Auxins in Plant Tissues.Methods Mol Biol. 2016;1398:37-53.

6.    Siligato R, Wang X, Yadav SR, Lehesranta S, Ma G, Ursache R, Sevilem I, Zhang J, Gorte M,  Prasad K, Wrzaczek M, Heidstra R, Murphy AS, Scheres B, Mähönen AP  (2015) MultiSite Gateway compatible cell type-specific gene inducible system for plants. doi:http://dx.doi.org/10.1104/pp.15.01246

7.    Kriegela A, Andrésa Z, Medzihradszkyb A, Krügera F, Scholla S, Delanga S, Patir-Nebioglua GM, Gute G, Yang H, Murphy AS, Peer WA, Pfeifferb A, Krebsa M, Lohmanna JU, Schumacher K (2015) Job Sharing in the Endomembrane System: Vacuolar Acidification Requires the Combined Activity of V-ATPase and V-PPase     Plant Cell tpc.15.00733         

8.    Tapken W and Murphy AS (2015) Membrane nanodomains in plants: capturing form, function, and movement. J Exp Bot 66: 1573-1586.

9.    Voß U, Wilson MH, Kenobi K, GouldPD, Robertson FC, Peer WA, Lucas M, Swarup K, Casimiro I, Holman TJ, Wells DM, Péret B, Goh T, Fukaki H, Hodgman TC, Laplaze L, Halliday KJ, Ljung K, Murphy AS, Hall AJ, Webb AAR, Bennett MJ. (2015) Lateral root organ initiation re-phases the circadian clock in Arabidopsis thaliana. Nature Communications, 6:7641 doi:10.1038/ncomms8641

10.  Hayashi K-I, Nakamura S, Fukunaga S, Jenness MK, Murphy, AS Motose H, Nozaki, H, Furutani M, Aoyama, T (2014) Auxin transport sites are visualized in planta using fluorescent auxin analogs. PNAS 111: 11557-11562  

11.  Yang H, Zhang X, Gaxiola RA,  Xu G,  Peer  WA,  Murphy AS (2014) Over-expression of the Arabidopsis proton-pyrophosphatase AVP1 enhances transplant survival, root mass, and fruit development under limiting phosphorus conditions. J. Exp. Bot 12: 3045-3053

12.  SpartzAK, Park M, RenH, Grandt K, LeeSH, MurphyAS, Gray W  (2014) SAUR inhibition of PP2C-D phosphatases activates plasma membrane H+-ATPases to promote cell expansion in Arabidopsis. Plant Cell, 26:2129-2142

13.  Marhavý P, Duclercq J, Weller B, Feraru E, Offringa R, Friml J, Schwechheimer K, Murphy M, Benková  E (2014)Cytokinin controls polarity of PIN1-dependent auxin transport during lateral root organogenesis. Current Biology, 24:1031-1037

14.  Peer WA, Jenness M, Murphy AS (2014) Measure for measure: determining, inferring, and guessing auxin gradients at the root tip. Physiologia Plantarum, 151: 97–111

15.  Yang H, Murphy AS (2013) Membrane Preparation, Sucrose Density Gradients and Two-phase Separation Fractionation from Five-day-old Arabidopsis seedlings. Bio-protocols. 1.12.14

16.  Sze H, Geisler M, Murphy AS (2013) Linking evolution of plant transporters to their functions. doi: 10.3389/fpls.2013.00547

17.  Li R, Qin G, Ljung K, Aoyama T, Liu J, Murphy AS, Gu H, Tsuge T, Qu LJ (2013) ADP1 affects plant architecture by regulating local auxin biosynthesis PLoS Genetics doi:10.1371/journal.pgen.1003954

18.  Garay-Arroyo A, Jaimes-Miranda F, Ortiz-Moreno E, Sánchez M, Murphy AS, Marsch-Martínez N, de Folter S, García-Ponce B, Corvera-Poiré A, Chávez Montes RA, Pacheco-Escobedo MA, Dubrovsky JG., Pelaz S, Alvarez-Buylla RE (2013)The MADS transcription factor XAL2/AGL14 modulates auxin transport during Arabidopsis root development by regulating PIN expression. EMBO 32: 2884-2895

19.  Peer WA, Cheng Y, Murphy AS (2013) Evidence of oxidative attenuation of auxin signaling. J. Exp. Bot. 64:2629-2639

20.  Yu H, Karampelias M, Robert S, Peer W, Swarup R, Ye S, Ge L, Cohen J, Murphy AS, Friml J, Estelle M (2013) ROOT UVB SENSITIVE 1/WEAK AUXIN RESPONSE 3 Is Essential for Polar Auxin Transport in Arabidopsis. Plant Physiology 162: 965-976

21.  Knapp DW, Peer WA, Conteh A, Diggs AR, Cooper BR, Glickman NW, Bonney PL, Stewart JC, Glickman LT, Murphy AS. (2013) Detection of herbicides in the urine of pet dogs following home lawn chemical application. Sci Total Environ. 456-457:34-41

22.  Yang H, Richter G, Wang X, Młodzińska E, Carraro N, Ma G, Jenness M, Chao D, Peer WA, Murphy AS (2013) Sterols and sphingolipids differentially function in trafficking of the Arabidopsis ABCB19 auxin transporter. Plant J. 74:37-47

23.  Janková Drdová E; Synek L, Pečenková T; Hála M; Kulich I; Fower J, Murphy A, Zarsky V (2012) The exocyst complex contributes to PIN auxin efflux carrier recycling and polar auxin transport in Arabidopsis  Plant J 73:709-19.

24. Ding Z,Wang B,Moreno I,Dupláková N,Simon S,Carraro N,Reemmer J,Pěnčík A,Chen X,Tejos R,Skůpa P,Pollmann S,Mravec J,Petrášek J,Zažímalová E,Honys D,Rolčík J,Murphy A,Orellana A,Geisler M,Friml J. (2012) ER-localized auxin transporter PIN8 regulates auxin homeostasis and male gametophyte development in Arabidopsis. Nature Comm 3: 941.

25.  Christie J, Murphy AS (2012) Shoot Phototropism in Higher Plants: New Light Through Old Concepts.  Am J. Botany 100:35-46

26.  Péret B, Swarup K, Ferguson A, Seth M, Yang Y, Dhondt S, James N, Casimiro I, Perry P, Syed A, Yang H, Reemmer J, Venison E, Howells C, Perez-Amador MA, Yun J, Alonso J, Beemster GT, Laplaze L, Murphy A, Bennett MJ, Nielsen E, Swarup R. (2012) AUX/LAX genes encode a family of auxin influx transporters that perform distinct functions during Arabidopsis development. Plant Cell24: 2874-2885.

27.  Murphy AS, Peer WA (2012) Vesicle Trafficking ROP/RIC Roundabout. Current Biol 22: R576-578.

28.  Dweikat I, Weil C, Ileleji K, Kochian LV, Moose SP, Brown PJ, Mosier NS, Murphy AS, Peer WA, McCann MC, Taheripour F, Carpita N (2012)  Envisioning the transition to a next-generation biofuels industry in the US Midwest Biofuels, Bioproducts & Biorefining DOI: 10.1002/bbb.1342

29.  Spartz AK, Lee SH, Wenger JP,  Gonzalez N, Itoh H,  Inze´ D, , Peer WA, Murphy AS, Overvoorde P, Gray WH (2012) The SAUR19 subfamily of SMALL AUXIN UP RNA genes promote cell expansion Plant J.  70: 978-990.

30.  Kubeš M, Yang H, Richter GL, Cheng Y, Młodzińska E, Wang X, Blakeslee JJ, Carraro N, Petrášek J, Zažímalová E, Hoyerová K , Peer WA and Murphy AS (2012) The Arabidopsis concentration-dependent influx/efflux transporter ABCB4 regulates cellular auxin levels in the root epidermis. Plant J. 69: 640-654.

31.  Bailly A, Yang H, Martinoia E, Geisler M, Murphy AS (2012) Plant lessons: exploring ABCB functionality through structural modeling. Frontiers in Plant Science, 2: 108.

32.  Hildreth S , Gehman  E, Yang  H, Lu R , Ritesh KC , Harich K , Yu  Shi, Lin J , Sandoe J, Okumoto  S, Murphy AS, Jelesko J (2011) A tobacco nicotine uptake permease affects alkaloid metabolism. Proc Nat Academy USA, 108: 18179-84.

33. Qi Y, Tsuda K,  Nguyen LV,  Wang X, Lin J,  Murphy AS, Glazebrook J,  Thordal-Christensen H, Katagiri F (2011) Physical association of Arabidopsis hypersensitive induced reaction proteins (HIRs) with the immune receptor RPS2. Biol Chem. 286: 31297-31307.

34.  Christie JM, Yang H, Richter GL, Sullivan S, Thomson C, Lin J, Titapiwatanakun B, EnnisM, KaiserliE, Lee OR, Adamec J, Peer WA, Murphy AS (2011)Phot1 Inhibition of ABCB19 Primes Lateral Auxin Fluxes in the Shoot Apex Required For Phototropism. PLoS Biology. 9:e1001076.

35.  Murphy AS (2011) Viewing transporter function in a pointillist landscape. (invited review)  Frontiers in Plant Science 2:14.

36.  DubrovskyJG,  Napsucialy-MendivilN, Duclercq J, ChengY, ShishkovaS, IvanchenkoMG, Friml J, Murphy AS, Benková E (2011) Auxin minimum defines a developmental window for lateral root initiation. New Phytologist 191: 970-983

37.  Peer WA, Blakeslee JJ, Yang H, Murphy AS. (2011). Seven things we think we know about auxin transport. Mol Plant 4: 487-504.

38.  Kim JI, Murphy AS, Baek D, Lee SW, Yun DJ,  Bressan RA, Narasimhan ML (2011) YUCCA6 overexpression demonstrates auxin function in delaying of leaf senescence in Arabidopsis thaliana. Exp Bot 62: 3981-3992.

39.  Tsuda E, Yang H, Nishimura T, Uehara Y, Sakai T, Furutani M, Koshiba T, Hirose M, Nozaki H, Murphy AS, Hayashi K (2010) Alkoxy-auxins are selective inhibitors of auxin transport mediated by PIN, ABCB and AUX1 transporters. Biol Chem. 286: 2354-2364.

40.  MonshausenG., Miller ND, Murphy AS,  Spalding EE, Gilroy S (2010) Dynamics of auxin-dependent Ca2+ and pH signaling in root growth revealed by integrating high resolution imaging with automated computer-vision-based analysis Plant. 65: 309-318.

41.  Baskin TI,  Peret B,  Baluška F,  Benfey PN,  Bennett M,  Forde BN, Gilroy S,  Helariutta Y,  Hepler PK,  Leyser O,  Masson PH,  Muday GK,  Murphy AS,  Poethig S,  Rahman A, Roberts K,  Scheres B,  Sharp RE,  Somerville C (2010) Shootward and rootward: peak terminology for plant polarity. Trends in Plant. 15: 593-594.

42.  McLamore ES, Diggs  A, Calvo Marzal P, Shi J, Blakeslee JJ, Peer WA, Murphy AS, Porterfield DM (2010) Non-invasive quantification of endogenous root auxin transport using an integrated flux microsensor technique. Plant. 64:1004-1016.

43.  Knöller AS, Blakeslee JJ, Richards EL, Peer WA, Murphy AS (2010) Brachytic2/ZmABCB1 functions in IAA export from intercalary meristems. Exp Bot. 61: 3689-96.

44.  Zažímalová E, Murphy AS, Yang H, HoyerováK, HošekP (2010) Auxin transporters - why so many? Auxin, O. Leyers Ed., CSH Perspectives in Biol March 2010;2:a001552

45.  Ge L, Peer WA, Murphy A, Robert S, Friml J, Ye S, Cohen J, Swarup R, Prigge M, Estelle M (2010) The Arabidopsis WAR1 (Weak AuxinResponse 1) gene is required for polar auxin transport and endosome recycling. Plant Cell, 22: 1749-1761.

46.  Růžička K, Strader L,  Bailly A, Yang H, Blakeslee J, Łangowski L,  Nejedlá E,Fujita H, Ito H, Syōno K, Hejátko J, Gray W, Martinoia E, Geisler M, Bartel B, Murphy AS, Friml J (2010) Arabidopsis PIS1 encodes the ABCG37 transporter of auxinic compounds including the auxin precursor indole-3-butyric acid Proc Nat AcademySci USA, 107: 10749-10753.

47.  Hosein FN, Bandyopadhyay A, Peer WA, Murphy AS. (2010) The catalytic and protein-protein interaction domains are required for APM1 function. Plant Physio 152: 2158-2172.

48.  Moore I and Murphy AS (2009) Validation of fluorescent protein fusions in endomembranes. (invited review) Plant Cell. 21:1632-1636.

49.  Peer WA, Hosein FN, Bandhyopadhyay A, Makam SN, Otegui M, Lee GJ, Blakeslee, JJ, Cheng Y, Titapiwatanakun B, Yakubov B, Bangari B, Murphy AS (2009) Mutation of the Membrane-Associated M1 Protease APM1 Results in Distinct Embryonic and Seedling Developmental Defects in Arabidopsis. Plant Cell, 21: 1693-1721.

50.  Yang H and Murphy AS (2009) Functional expression and characterization of Arabidopsis ABCB, AUX1 and PIN auxin transporters in Schizosaccharomyces pombe. Plant J 59:159-171.

51.  Titapiwatanakun B, Blakeslee JJ, Bandyopadhyay A, Sauer M, Mravec J, Cheng Y, Adamec J, Nagashima A, Geisler M, Sakai T, Friml J, Peer WA, Murphy AS (2009) PGP19/ABCB19 stabilises PIN1 in plasma membrane microdomains in Arabidopsis. Plant, 57:27-44 I.

52.  Frommer W, Schulz B, Murphy A (2008) Evaluating the function of putative hormone transporters. Plant Sig Behav.

53.  Titapiwatanakun B and Murphy AS (2009) Post-transcriptional regulation of auxin transport proteins: cellular trafficking, protein phosphorylation, protein maturation, ubiquitination, and membrane composition. J. Exp. Botany, 60:1093-1107.  

54.  Li, H, Cheng Y, Hagen G, Murphy AS, Guilfoyle T (2008) Constitutive Repression and Activation of Auxin Signaling in Arabidopsis. Plant Physiol, 149: 1277-88.

55.  Verrier PJ,  Bird D, DassaE, ForestierC, GeislerM, KleinM, KolukisaogluU,  LeeY, MartinoiaE, MurphyA, SamuelsL, SchulzB, SpaldingE, Yazaki  K, TheodoulouFL (2008) Update on plant ABC proteins: a unified nomenclature for a large and diverse superfamily. Trends in Plant Sci. 13:151-159

56.  Peer WA, Murphy AS (2007) Flavonoids and auxin transport: regulators or modulators. Trends in Plant Sci. 12: 556-563.

57.  Alpi A, Amrhein N, Bertl A, alphabetical list 33 total authors, Taiz L, Thiel G, Wagner, R (2007) Plant neurobiology: no brain, no gain? Trends in Plant Sci. (2007) 12(4):135-6. Epub 2007 Mar 23

58.  Blakeslee JJ, Bandyopadhyay A, Lee OR, Sauer M, Mravec J, Titapiwatanakun B, Geisler M, Nagashima A, Sakai T, Martinoia E, Friml J, Peer WA, Murphy AS (2007) Interactions among PINFORMED (PIN) and P-glycoprotein (PGP) auxin transporters in Arabidopsis thaliana.  Plant Cell, 19: 131-147.

59.  Green R, Schulz B, Murphy AS, Watkins B, Ferruzzi M (2007) Common tea formulations modulate in vitro digestive recovery of green tea catechins. Mol Nutri & Food Res. 51:1152-1162.

60.  Jain A, Poling M, Karthikeyan A, Blakeslee JJ, Peer WA, Titapiwatanakun B, Murphy AS, Raghothama K (2007) Differential effects of sucrose and auxin on localized Pi-deficiency induced modulation of different traits of root system architecture in Arabidopsis.  Plant Physio.  144: 232-247.

61.  Kim JI, Sharkhuu A, Jin JB, Li P, Jeong JC, Baek D, Lee SY, Blakeslee JJ, Murphy AS, Bohnert HJ, Hasegawa PM, Yun DJ, Bressan RA (2007) yucca6, a dominant mutation in Arabidopsis, affects auxin accumulation and auxin- related phenotypes. Plant Physiol. 145:1073-1085.

62.  Rojas-PierceM, Titapiwatanakun B, Sohn EJ,  Fang F, Larive CK,  Blakeslee JJ ,  PeerWA, Murphy AS, Raikhel NV (2007) Inhibition of gravitropism by gravacin is mediated by Arabidopsis P-glycoprotein19.  Chemistry and Biology (Cell Press), 14, 1366-1376

63.  Shin R, Burch AY, Huppert KA , Tiwari SB, Murphy AS , Guilfoyle  TJ, Schachtman  DP (2007) The Arabidopsis transcription factor MYB77 modulates auxin signal transduction.  Plant Cel.l19:2440-2453.

64.  Yang H, Knapp J, Landry E, Peer WA, Silbart L, Murphy A, Gaxiola R (2006) Enhanced phosphorus nutrition in dicot and monocot crop plants overexpressing a phorsphorus-responsive H+-pyrophosphatase. Plant Biotech J.  5:735-745.

65.  Bandhyopadhyay A, Blakeslee JJ, Lee OR, Titapiwatanakun B, Bouchard R, Geisler M, Martinoia E, Peer WA, Murphy AS (2006) Interactions of PIN and PGP auxin transport mechanisms.  Biochemi Soc Trans.35:137-141.    

66.  Bouchard R, Vincenzetti V, Blakeslee JJ, Bailly A, Lee OR, Popanov I, Palme K,  Murphy AS, Schulz B, Geisler M (2006) Functional interaction between the immunophilin-like protein TWD1 and P-glycoprotein PGP1.  J Bio Chemi. 281:30603-30612.

67.  Friml J, Murphy AS (2006) Nomenclature for apical/basal polarity in plants. Web Essay, In Plant Physiology, fourth edition, Taiz L, Zeiger E, Eds. Sinauer Associates, Sunderland MA.

68.  Orlova I, Schnepp J, Marshall A, Qualley A, Varbanova M, Blakeslee JJ, Peer WA, Murphy AS, Rhodes D, Pichersky E, Dudareva N (2006) Reductions in the synthesis of benzenoids in petunia flowers reveals multiple pathways to benzoic acid and an unexpected enhancement of auxin transport.  Plant Cell 18: 3458-3475.

69.  Peer WA, Mahmoudian M, Lahner B, Richards EL, Reeves RD, Murphy AS, Salt DE. (2006) Assessment of plant from the Brassicaceae family as genetic models for the study of nickel and zinc hyperaccumulation.  New Phytologist 170: 239-260.

70.  Petrášek J, Mravec J, Bouchard R, Blakeslee JJ, Aba L, Tadele Z, Perry L,  Křeček P, Čovanová M, Skůpa P, Lee OR,  Benková E, Fink G, Geisler M, Murphy AS, Luschnig C, Zažímalová E, Friml J (2006) PIN proteins are auxin efflux catalysts determining both quantity and direction of auxin flow in plants.  Science 312: 914-918.

71.  Baluska F, Barlow P, Baskin T, Chen R, Feldman L, Forde B, Geisler M, Jernstedt J, Menzel D, Muday G, Murphy A, Samaj J, Volkmann D (2005) What is apical and what is basal in plant root development. Trends in Plant Sci. 10: 409-411.

72.  Blakeslee JJ, Peer WA, Murphy AS (2005) Auxin Transport. (invited review) Current Opinion in Plant Biol.  8: 494-500.  )

73.  Choi G, Kim JI, Hong SW, Shin B, Choi G, Blakeslee JJ, Murphy AS, Seo Y, Kim K, Koh EJ, Song PS, Lee H (2005) A possible role of NDPK2 in the regulation of auxin mediated responses for plant growth and development.  Plant Cell Physiol. 48:1246-1254.

74.  Geisler M, Blakeslee JJ, Bouchard R, Lee OR, Vincenzetti V, Bandyopadhyay A , Peer WA , Smith AP, Baroux C, Grossniklaus U, Müller A, Dudler R, Murphy AS, Marintoia, E (2005) Cellular efflux of auxin mediated  by the Arabidopsis MDR/PGP transporter AtPGP1.  Plant J. 44:179-194.

75.  Geisler and Murphy (2005) The ABCs of plant p-glycoprotein transporters. FEBS Letts580:1094-1102.

76.  Li J, Yang H, Richter G, Blakeslee JJ, Bandyopadhyay A, Peer WA, Titapiwantakun B , Richards E, Undurraga S, Murphy AS , Gilroy S,Gaxiola R (2005) The H+-PPase AVP1 is required for organ development in Arabidopsis. Science. 310:121-125.

77.  Murphy AS, Bandhyopadhyay A, Holstein S, Peer WA (2005) Endocytotic cycling of plasma membrane proteins in Arabidopsis. (invited review)   Ann Rev Plant Biol. 56: 221-251.

78.  TerasakaK,  BlakesleeJJ, Titapiwatanakun B, BandyopadhyayA, PeerWA, MurphyAS, Sato F, Yazaki K (2005) AtPGP4, an ATP-binding cassette P-glycoprotein, catalyzes auxin transport in Arabidopsis thaliana roots.  Plant Cell, 17: 2922-2939.

79.  BaxterIR, ArmstrongG, Foster N, Peer WA, Hazen SP, Murphy AS, HarperJF, Young JC (2004) A Plasma Membrane H+ ATPase Is required for the formation of proanthocyanidins in the seed coat endothelium of Arabidopsis thaliana.  Proc Nat Academy of Sci. USA:102: 2649-2654.

80.  Blakeslee JJ, Bandyopadhyay A, Peer WA, Makam SN, Murphy AS (2004) PIN1 auxin efflux facilitator plays a role in phototropism.  Plant Physiol. 134: 28-31.

81.  Makam SN, Peer WA, Blakeslee JJ, Murphy AS (2004) Cultural practices contributing to Mature Watermelon Vine Decline.  Hort Science. 40: 597-601.

82.  Peer WA, Bandyopadhyay A, Blakeslee JJ, Srinivas MN, Chen R, Masson P, Murphy AS (2004)Variation in PIN gene expression and protein localization in flavonoid mutants with altered auxin transport. Plant Cell. 16: 1898-1911.

83.  GeislerM, KolukisaogluHU, BillionK, Berger J, SaalB, BouchardR, FrangneN, Koncz-KálmánZ, KonczC, DudlerR, BlakesleeJJ, MurphyAS, MartinoiaE, and Schulz B (2003) TWISTED DWARF1, a unique plasma membrane-anchored immunophilin-like protein, interacts with Arabidopsis multi-drug resistance-like transporters AtPGP1 and AtPGP19.  Mol Biol Cell. 10: 4238-4249.

84.  Muday GK, Peer WA, Murphy AS (2003) Vesicular cycling mechanisms that control auxin transport polarity. Trends Plant Science. 8: 301-304.

85.  Multani DS, Briggs S, Chamberlin MA, Blakeslee JJ, Murphy AS, Johal G (2003) Control of plant height in maize by an ABC transporter of the multi-drug resistance class.  Science. 302: 81-84.

86.  Noh B, Bandyopadhyay A, Peer WA, Spalding EP, Murphy AS (2003) Enhanced gravi- and phototropism in plant mdr mutants mislocalizing the auxin efflux protein PIN1.  Nature. 423: 999-1002.

87.  Peer WA, MamoudianM, LahnerB, ReevesRD, MurphyAS, SaltDE (2003) Identifying model metal hyper accumulating plants: germplasm analysis of 20 Brassicaceae accessions from a wide geographical area.  New Phytol. 159: 421-430. (48/58)

88.  Peer WA, Murphy AS (2003) Floral scent of Arabidopsis (Brassicaceae).  Biochemi System Ecol. 31: 1193-1195.

89.  SurpinM, ZhengH, MoritaMT, SaitoC, Avila-TeeguardenE, Blakeslee JJ, Bandyopadhyay A, MurphyAS, KovalevaV, Carter D, TasakaM, Raikhel N (2003) The VTI family of SNARE proteins is necessary for plant viability and mediates different protein transport pathways.  Plant Cell. 15: 2885-2899.

90.  Smith AP, Nourizadeh SD, Peer WA, Xu J, Bandyopadhyay A, Murphy AS and Goldsbrough PB (2003) Arabidopsis AtGSTF2 is regulated by ethylene and auxin, and encodes a glutathione S-transferase that interacts with flavonoids.  Plant J. 36: 433-442.

91.  Muday GK, Murphy AS (2002) An emerging model of auxin transport regulation. (Invited review) Plant Cell 14 (2) 293-299.

92.  Murphy AS, Hoogner K, Peer WA, Taiz L (2002) Identification, purification, and molecular cloning of N-1-naphthylphthalmic acid -binding plasma membrane-associated amino peptidases from Arabidopsis. Plant Physiol. 128: 935-950.

93.  Murphy AS (2002) Exploring the cellular basis of auxin transport. In Plant Physiology. Taiz L, Zeiger E, eds. Sinauer Associates, Sunderland MA.

94.  Brown DE, Rashotte AM, Murphy AS, Tague BW, Peer WA, Taiz L, Muday GK (2001)  Flavonoids act as negative regulators of auxin transport in vivo in Arabidopsis.  Plant Physiol. 126: 524-535.

95.  Noh B, Murphy AS, Spalding E (2001) Multi-drug Resistance-like genes of Arabidopsis required for auxin transport and auxin-mediated development.  Plant Cell. 13: 2441-2454.

96.  Peer WA, Brown DE, Tague BW, Muday GK, Taiz L, Murphy AS (2001) Flavonoid accumulation patterns of transparent testa mutants of Arabidopsis.  Plant Physiol. 126: 536-548.

97.  Murphy, A, Peer W, Taiz L. (2000) Regulation of auxin transport by aminopeptidases and endogenous flavonoids.  Planta. 211: 315-324.

98.  Murphy, A, Eisinger W, Shaff J, Kochian L, Taiz L. (1999) Early copper-induced leakage of K+ from Arabidopsis seedlings is mediated by ion channels and coupled to citrate efflux.  Plant Physiol. 121: 1375-1382.

99.  Murphy A, Taiz L. (1999) Copper responses in the model plant Arabidopsis thaliana. WW Wenzel, Ed., Publisher: International Society for Trace Element Research, Vienna Austria.

100.  Murphy A, Taiz L. (1999) Naphthylphthalamic acid is enzymatically hydrolyzed at the hypocotyl-root transition zone and other tissues of Arabidopsis seedlings.  Plant Physiol Biochemi. 37: 413-430.

101.   Murphy A, Taiz L. (1999) Localization and characterization of soluble and plasma membrane aminopeptidase activities in Arabidopsis seedlings.  Plant Physiol Biochem. 37 :431-443.

102.  Garcia-Hernandez M, Murphy A, Taiz L. (1998) Metallothioneins 1 and 2 have distinct but overlapping expression patterns in Arabidopsis thaliana.  Plant Physiol. 118:387-397.

103.  Murphy A, Taiz L. (1997) Correlation between potassium efflux and copper sensitivity in 10 Arabidopsis ecotypes.  New Phyt. 136: 211-222.

104.Murphy A, Zhou J, Goldsbrough P, Taiz L. (1997) Purification and immunological identification of metallothioneins 1 and 2 from Arabidopsis thaliana.  Plant Physiol. 113: 1293-1301.

105.  Murphy A, Taiz L. (1995) Comparison of metallothionein gene expression and non protein thiols in ten Arabidopsis ecotypes.  Correlation with copper tolerance.  Plant Physiol. 109: 945-954.

106.   Murphy A, Taiz L. (1995) A new vertical mesh transfer technique for metal-tolerance studies in Arabidopsis-ecotypic variation and copper-sensitive mutants.  Plant Physiol. 108: 29-38.

Books

1.    Evolution of Membrane Signaling and Trafficking in Plants (2013) Geisler M, Murphy AS, Sze Frontiers Media SA, Geneva,  ISBN: 978-2-88919-131-4

2.    The Plant Plasma Membrane (2010)Murphy AS, Peer WA, Schulz B, Eds. Springer Verlag, Heidelberg.   

3.    Plant Physiology and Development (6th edition 2014) co-author with Lincoln Taiz, Eduardo Zeiger, Max Moeller, Sinauer Press, Sunderland, MA.

Book chapters

1. Jenness M and Murphy AS (2014) Evolution of Transport Directionality in ABCBs. In Plant ABC Transporters  Markus Geisler, Ed. Springer, Berlin.

2. Knöller AS, Murphy AS (2010) ABC transporters and their function at the plasma membrane The Plant Plasma Membrane, Plant Cell Monographs, Springer, Berlin.

2. Murphy AS  (2010) Auxin: the first growth hormone. In Plant Physiology, 5th Edition, L Taiz and E Zeiger, eds,  Sinauer Associates, Sunderland MA.

3.  Peer WA, Murphy AS (2008) Flavonoid signaling: targets of flavonoid action. In The Science of Flavonoids, 2nd edition, Erich Grotewald Ed, Springer Verlag, New York.

4. Murphy AS (2006) Auxin: the Growth Hormone. In Plant Physiology, fourth edition, Taiz L,  Zeiger E, Eds. Sinauer Associates, Sunderland MA.

5. Peer WA, Baxter IR, Richards EL, Freeman JL, Murphy AS (2005) Phytoremediation and Hyperaccumulator Plants. In Molecular Biology of Metal Homeostasis and Detoxification; from microbes to man’ in the book series Topics in Current Genetics, LWJ Klomp, E Martinoia, MJ Tamás, eds. Springer. Berlin 2006.

6. Peer WA, Murphy AS (2005) Flavonoid signaling. In The Science of Flavonoids, Erich Grotewald Ed, Springer Verlag New York.

7. Blakeslee JJ, Peer WA, Murphy AS (2005) Endocytotic cycling of MDR/PGPs. Plant Endocytosis, Frantisek Baluska and Jozef Samaj, Eds. Elsevier, Berlin 159-176.

8.  Murphy AS (2002) Auxin: the Growth Hormone. In Plant Physiology, Taiz L, Zeiger E, eds. Sinauer Associates, Sunderland MA.