2021- , Assistant Professor, Virology, Department of Animal and Avian Sciences, University of Maryland, College Park, MD, USA
2020-2021, Teaching Fellow, Immunology & Virology, School of Veterinary Medicine, University of Surrey, UK
2019-2021, Group Leader, The Pirbright Institute, UK
2014-2019, Research Fellow, The Pirbright Institute, UK
2010-2014, Postdoctoral Visiting Fellow, Virology, National Institutes of Health (NIH), Bethesda, MD, USA
2006-2010, PhD, Microbiology & Immunology, Imperial College London, UK
2005-2006, MSc, London School of Hygiene and Tropical Medicine, UK
2002-2005, VetMB, Veterinary Medicine, University of Cambridge, UK
1999-2002, MA, Pathology, University of Cambridge, UK
2022: Reddy VRAP, Nazki S., Brodrick A.J., Asfor A., Urbaniec J., Morris Y., Broadbent A. J. Evaluating the breadth of neutralizing antibody responses elicited by infectious bursal disease virus (IBDV) genogroup A1 strains using a novel chicken B-cell rescue system and neutralization assay. Journal of Virology, 2022, Sep 7;e0125522.doi: 10.1128/jvi.01255-22
2022: Reddy VRAP, Campbell EA, Wells J, Simpson J, Nazki S, Hawes PC, Broadbent AJ. Birnaviridae virus factories show features of liquid-liquid phase separation, and are distinct from paracrystalline arrays of virions observed by electron microscopy. Journal of Virology, 2022, Feb 9;jvi0202421. doi: 10.1128/jvi.02024-21.
2021: Asfor A, Nazki S, Reddy VRAP, Campbell E, Dulwich KL, Giotis ES, Skinner MA, Broadbent AJ. Transcriptomic Analysis of Inbred Chicken Lines Reveals Infectious Bursal Disease Severity Is Associated with Greater Bursal Inflammation In Vivo and More Rapid Induction of Pro-Inflammatory Responses in Primary Bursal Cells Stimulated Ex Vivo. Viruses, 2021, 13(5), 933; doi: 10.3390/v13050933
2020: Dulwich KL, Gray A, Asfor A, Giotis S, Skinner M, Broadbent AJ. The stronger downregulation of in vitro and in vivo innate antiviral responses by a very virulent strain of infectious bursal disease virus (IBDV), compared to a classical strain, is mediated, in part, by the VP4 protein. Frontiers in Cellular and Infection Microbiology, 2020, June 9, 10.315. doi: 10.3389/fcimb.2020.00315
2020: Campbell E, Gray A, Skinner M, Jennifer Simpson, Pippa Hawes, Broadbent AJ. Discrete virus factories form in the cytoplasm of cells co-infected with two strains of the segmented dsRNA virus, infectious bursal disease virus (IBDV), that subsequently coalesce. Journal of Virology, 2020, Jun 16; 94 (13), e-02107-19, doi: 10.1128/JVI.02107-19.
2018: Dulwich KL, Asfor AS, Gray AG, Nair V, Broadbent AJ. An ex vivo chicken primary bursal-cell culture model to study infectious bursal disease virus pathogenesis. Journal of Visualized Experiments, 2018; Oct 4; (140); doi: 10.3791/58489
2018: Sadigh Y, Powers C, Spiro S, Pedrera M., Broadbent A, Nair V. Gallid hepesvirus 3 SB-1 strain as a recombinant viral vector for poultry vaccination. NPJ Vaccines, 2018; May 28; 3:21; doi: 10.1038/s41541-018-0056-6
2018: Soubies S, Courtillon C, Abed M, Amelot M, Keita A, Broadbent A, Härtle S, Kaspers B, Eterradossi N. Propagation and titration of infectious bursal disease virus, including non-cell- culture-adapted strains, using ex vivo-simulated chicken bursal cells. Avian Pathology, 2017; Jan; doi: 10.1080/03079457.2017.1393044
2017: Dulwich KL, Giotis ES, Gray A, Nair V, Skinner M, Broadbent AJ. Differential gene expression in chicken primary B cells infected ex vivo with attenuated and very virulent strains of infectious bursal disease virus (IBDV). Journal of General Virology, 2017; 98:2918-2930; doi:10.1099/jgv.0.000979
2017: Ciccone NA, Smith LP, Mwangi W, Boyd A, Broadbent AJ, Smith AL, Nair V. Early pathogenesis during infectious bursal disease in susceptible chickens is associated with changes in B cell genomic methylation and loss of genome integrity. Developmental and Comparative Immunology, 2017 Mar; doi: 10.1016/j.dci.2017.03.014.
2017: Houser KV, Broadbent AJ, Gretebeck L, Vogel L, Lamirande EW, Sutton T, Bock KW, Minai M, Orandle M, Moore IN, Subbarao K. Enhanced inflammation in New Zealand white rabbits when MERS-CoV reinfection occurs in the absence of neutralizing antibody. PLoS Pathogens, 2017 Aug 17; 13(8):e1006565; doi: 10.1371/journal.ppat.1006565
2016: Broadbent AJ, Santos CP, Anafu A, Wimmer E, Mueller S, Subbarao K. Evaluation of the attenuation, immunogenicity, and efficacy of a live virus vaccine generated by codon-pair bias de-optimization of the 2009 pandemic H1N1 influenza virus in ferrets. Vaccine, 2016 Jan 20; 3(4): 563-570; doi: 10.1016/j.vaccine.2015.11.054.
2015: Broadbent AJ, Santos CP, Paskel M, Matsuoka Y, Lu J, Chen Z, Jin H, Subbarao K. Replication of live attenuated cold-adapted H2N2 influenza virus vaccine candidates in non human primates. Vaccine, 2015 Jan 1; 33(1): 193-200; doi: 10.1016/j.vaccine.2014.10.065.
2014: Broadbent AJ, Santos CP, Godbout R, Subbarao K. The Temperature-Sensitive and Attenuation Phenotypes Conferred by Mutations in the Influenza Virus PB2, PB1, and NP Genes Are Influenced by the Species of Origin of the PB2 Gene in Reassortant Viruses Derived from Influenza A/California/07/2009 and A/WSN/33 Viruses. Journal of Virology, 2014 Nov 1; 88(21): 12339-12347; doi: 10.1128/JVI.02142-14.
2014: Lakdawala SS, Wu Y, Wawrzusin P, Kabat J, Broadbent AJ, Lamirande EW, Fodor E, Altan-Bonnet N, Shroff H, Subbarao K. Influenza A virus assembly intermediates fuse in the cytoplasm. PLoS Pathogens, 2014 Mar 6;10(3):e1003971; doi:10.1371/journal.ppat.1003971.
Dr Sofia Egana-Labrin, Postdoctoral Research Associate, 2022-present, University of Maryland, USA
Dr Vishi Reddy, Senior Postdoctoral Research Scientist, 2020-present, The Pirbright Institute, UK
Dr Salik Nazki, Postdoctoral Research Scientist, 2020-present, The Pirbright Institute, UK
Dr Amin Asfor, Postdoctoral Research Scientist, 2017-2020, The Pirbright Institute, UK
Andrew Brodrick, 2021-present, University of Maryland, USA
Yana Chen, 2021-present, The Pirbright Institute, UK
Kate Dulwich, 2015-2019, The Pirbright Institute, UK
Joanna Urbaniec, 2019, The Pirbright Institute, UK
Yasmin Morris, 2019, The Pirbright Institute, UK
Rebecca Daines, 2017, The Pirbright Institute, UK
Rebecca Moore, 2017, The Pirbright Institute, UK
Undergraduate and Placement students
Declan Kehlbeck, 2022-, University of Maryland, USA
Shelley Wang, 2022, University of Maryland, USA
Alisha Van Eck, 2021-2022, University of Maryland, USA
Elle Campbell, 2018-2019, The Pirbright Institute, UK
Alice Gray, 2016-2017, The Pirbright Institute, UK
Google Scholar: https://scholar.google.co.uk/citations?user=YAzMzXQAAAAJ&hl=en