Genome Editing/ Genetic Engineering of Livestock: The availability of genome editors, primarily CRISPR/Cas system is facilitating precise editing of the animal genomes and is heralding a new age in animal biotechnology. Our laboratory extensively employs genome editing in porcine and other large animal models to address critical priorities of animal and human health.
Stem Cells and Regenerative Medicine: In our laboratory, we employ embryonic and induced pluripotent stem cell lines from mouse, pig and humans for regenerative medicine applications. Specifically, we utilize these tools as a proxy to model developmental pathways that are critical for fate specification and development of committed cell types in vivo. Also, in combination with the murine and porcine models, we are investigating the potential of embryonic or committed progenitor cells in cellular therapy and organ development.
Reproductive Biology/Developmental Biology: Utilizing CRISPR/cas system in murine models, we are investigating early events of trophectoderm differentiation and placenta formation in mouse models.